The endocannabinoid system was first characterized in the late 1980’s and early 1990’s. It is a central regulatory system that affects a wide range of biological processes similar to our immune system, nervous system, and all of the body’s organs. CBD helps bring your entire body back into balance… not just one single area (like most supplements).
Endogenous Cannabinoid System and Exogenous Cannabinoids
First of all, endogenous cannabinoids, or endocannabinoids, are produced by cells in the human body. The two major endocannabinoids are anandamide and 2-arachidonoylglycerol (2-AG); hence, they are considered our natural form of THC. This system runs throughout the entire body and, as a result, is responsible for general health and is arguably one of the most important of our physiological systems. Furthermore, 2-AG is found in the central nervous system and plays a role in immune function, pain management and appetite. These cannabinoids function as neurotransmitters; as a result, they are only produced when the body needs them. (Isn’t our endocannabinoid system amazing?)
Exogenous cannabinoids, which are produced outside of the body, are also capable of binding to and activating cannabinoid receptors. Phytocannabinoids, produced by plants, are a natural source of these chemical transmitters.
The most noteworthy phytocannabinoid is tetrahydrocannabinol (THC), and is the only cannabinoid which produces psychoactive effects, or the “high” experienced by marijuana smokers. CBD, CBN CBG, CBC and terpenes provide a list of medicinal health benefits without the psychoactive results.
What are Cannabinoid Receptors?
For cannabinoids to positively influence the body, they require communication with cannabinoid receptors. There are two cannabinoid receptors within the human body: CB1 and CB2.
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CB1 receptors are primarily found in the brain and central nervous system and connective tissue, but can also be found in peripheral organs. effecting such brain functions as decision making, cognitive, creativity, memory, emotion, sleep responses, appitite and many more,
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CB2 receptors are mostly found in the immune and lymphatic systems and are responsible for such bodily functions as metabolism, digestion, pain perception, energy balance, bone growth and blood pressure.
It is for these reasons that we must always strive to achieve a balanced system. Research is accumulating that shows that CB1 dominance is associated with increased perception of stress, anxiety, paranoia augmented appetite, and decreased nausea and vomiting and pain perception, and a host of other issues.
Cannabinoids & Chronic Disease
For individuals experiencing certain chronic medical conditions or diseases, cannabinoids can impact the severity of symptoms according to pre-clinical studies and research. Most-importantly, cannabinoid-based treatments are on the rise to help patients experience symptomatic relief from:
- Chronic pain
- Inflammatory diseases such as arthritis, ulcerative colitis, and myofascial pain syndrome
- Psychological conditions such as depression, anxiety, and insomnia
- Glaucoma
- Asthma
- Cardiovascular disease
The Potential of the Human Endocannabinoid System
Therefore, the human endocannabinoid system is unique and complex, and it is a system we are still just beginning to comprehend. Pre-clinical studies have indicated that by modulating endocannabinoid system activity, there is therapeutic potential in almost all disease states that affect humans.
With absolutely unmatched potential, focusing on the endocannabinoid system in humans could reap health benefits not previously experienced with other pharmacological therapies.